Brucellar Spondylodiscitis In a Critically Ill Patient With Paraparesis
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چکیده
Brucellosis, is a systemic infection disease that is caused by Brucella bacteries. Bacteries cause infection by ingestion of unsterilized milk or meat of infected animals, close contact with their secretions, inhalation of infected aerosol or inoculation to conjunctivas (1, 2). A genus of Gram-negative bacteria, non-motile, non-encapsulated coccobacilli brucella bacteries causes symptoms 1-3 weeks after entering into the body (2). The disease generally begins with weakness, fever, sweating, hepatosplenomegaly, lymphadenopathy, pancitopenia, osteoarticular (back pain, arthiritis, arthralgia, myalgia) and rarely respiratory system (coughing, bronchopneumonia, pleural effusion) symptoms and sings (2-6).
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Blood samples and a bone biopsy specimen from one patient diagnosed with spondylodiscitis of unknown etiology were analyzed by quantitative real-time PCR to detect Brucella melitensis. The high sensitivity and specificity of this assay allowed the diagnosis of brucellar spondylitis within 24 h, a result that we were unable to obtain through the use of conventional methods.
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INTRODUCTION Brucellosis is an endemic zoonosis in Portugal. Brucellar spondylodiscitis is one of the most frequent focal manifestations which may cause severe sequelae despite appropriate therapy. MATERIAL AND METHODS Retrospective study of patients with diagnosis of brucellar spondylodiscitis admitted to the Infectious Diseases Department of Centro Hospitalar e Universitário de Coimbra, ove...
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تاریخ انتشار 2014